Juvenile systemic lupus erythematosusA chronic disease that causes systemic inflammation which affects multiple organs. Learn more. (JSLEJuvenile systemic lupus erythematosus is an autoimmune disorder characterized by inflammatory damage to joints, kidney, central nervous system, and hematopoietic system in the form of...) is an autoimmuneAny disorder in which loss of function or destruction of normal tissue arises from humoral or cellular immune responses to the body’s own tissue constituents.... disorder characterized by inflammationInflammation is a normal part of the body’s defense to injury or infection, and, in this way, it is beneficial. But inflammation is damaging when... and damage in the joints, kidneys, and central nervous systemThe central nervous system (CNS) consists of the brain and spinal cord. This body system is responsible for integrating and coordinating the activities of the..., among other parts of the body. Juvenile dermatomyositisJuvenile dermatomyositis (JDM) is a disease in children that causes skin rash (dermato) and muscle inflammation (myositis). It results in weak muscles. JDM is a... (JDMJuvenile dermatomyositis (JDM) is a disease in children that causes skin rash (dermato) and muscle inflammation (myositis). It results in weak muscles. JDM is a...) is a rare inflammatoryInflammation is a normal part of the body’s defense to injury or infection, and, in this way, it is beneficial. But inflammation is damaging when... disease that causes muscle weakness and skin rash. Although all age and ethnic groups can be affected by the diseases, they often strike earlier in life, including during the teen years and sometimes even earlier.
In the long-term, JSLEJuvenile systemic lupus erythematosus is an autoimmune disorder characterized by inflammatory damage to joints, kidney, central nervous system, and hematopoietic system in the form of... and JDMJuvenile dermatomyositis (JDM) is a disease in children that causes skin rash (dermato) and muscle inflammation (myositis). It results in weak muscles. JDM is a... can have serious health consequences, as these patients have unusually high rates of hypertensionHigh blood pressure., chronicChronic diseases are defined broadly as conditions that last 1 year or more and require ongoing medical attention or limit activities of daily living or... inflammationInflammation is a normal part of the body’s defense to injury or infection, and, in this way, it is beneficial. But inflammation is damaging when..., and obesityWeight that is higher than what is considered healthy for a given height is described as overweight or obesity.. By young adulthood, people with JSLEJuvenile systemic lupus erythematosus is an autoimmune disorder characterized by inflammatory damage to joints, kidney, central nervous system, and hematopoietic system in the form of... and JDMJuvenile dermatomyositis (JDM) is a disease in children that causes skin rash (dermato) and muscle inflammation (myositis). It results in weak muscles. JDM is a... have up to eight times higher risk of developing cardiovascular disease than their peers.
Exacerbating the issue are the high stress levels that often accompany these conditions. Fortunately, stress is a modifiable risk factor.
“There is an urgent need to develop and test intervention strategies for children with JSLEJuvenile systemic lupus erythematosus is an autoimmune disorder characterized by inflammatory damage to joints, kidney, central nervous system, and hematopoietic system in the form of... and JDMJuvenile dermatomyositis (JDM) is a disease in children that causes skin rash (dermato) and muscle inflammation (myositis). It results in weak muscles. JDM is a...,” said lead investigator Kaveh Ardalan, MD, MS, a pediatric rheumatologist and researcher with Duke Health in North Carolina. “Children with JSLEJuvenile systemic lupus erythematosus is an autoimmune disorder characterized by inflammatory damage to joints, kidney, central nervous system, and hematopoietic system in the form of... and JDMJuvenile dermatomyositis (JDM) is a disease in children that causes skin rash (dermato) and muscle inflammation (myositis). It results in weak muscles. JDM is a... need early interventions that change the trajectory of their cardiovascular health as they move through childhood, begin college, plan careers, and pursue personal goals.”
According to Dr. Ardalan, high stress and chronicChronic diseases are defined broadly as conditions that last 1 year or more and require ongoing medical attention or limit activities of daily living or... inflammationInflammation is a normal part of the body’s defense to injury or infection, and, in this way, it is beneficial. But inflammation is damaging when... in JSLEJuvenile systemic lupus erythematosus is an autoimmune disorder characterized by inflammatory damage to joints, kidney, central nervous system, and hematopoietic system in the form of... and JDMJuvenile dermatomyositis (JDM) is a disease in children that causes skin rash (dermato) and muscle inflammation (myositis). It results in weak muscles. JDM is a... patients create a perfect storm of illness, inflicting significant damage on cardiovascular health and heart diseaseHeart disease describes a range of conditions that affect the heart. Learn more. risk. At the same time, patients can address their disease with lifestyle modifications, including stress reduction. This research project is designed to help accomplish this goal, helping us understand how stress affects inflammationInflammation is a normal part of the body’s defense to injury or infection, and, in this way, it is beneficial. But inflammation is damaging when... and cardiovascular health in people with JSLEJuvenile systemic lupus erythematosus is an autoimmune disorder characterized by inflammatory damage to joints, kidney, central nervous system, and hematopoietic system in the form of... and JDMJuvenile dermatomyositis (JDM) is a disease in children that causes skin rash (dermato) and muscle inflammation (myositis). It results in weak muscles. JDM is a... and searching for ways to develop stress reduction interventions.
When the study is complete, investigators plan to create a framework that explains how stress, inflammationInflammation is a normal part of the body’s defense to injury or infection, and, in this way, it is beneficial. But inflammation is damaging when..., and cardiovascular health are interconnected in pediatric-onset rheumatic diseases with a goal of creating stress reduction interventions that can improve both emotional and cardiovascular health.
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